Chest 132 , 12471252 (2007)
Cysteine is a precursor of glutathione, while methionine can synthesize glutathione through the transsulfuration pathway, which can also use homocysteine to create glutathione
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Mitochondrial dysfunction leading to oxidative stress also induces FGF21 expression in preclinical disease models (110), while levels of FGF21 are elevated in the circulation and skeletal muscle of patients with myopathies caused by mutations in components of the mitochondrial oxidative phosphorylation machinery (111)
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